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Publicaties S. Hughes

  • Schön, J.L., Weinert, J., Popkova, Y., Hughes, S., Schiller, J., Schöneberg, T., Prömel, S. The PCP protein FMI-1 regulates body size and fat storage through Insulin/IGF-1-like signalling. (manuscript in preparation, submission to Neuron)
  • Kikken, C., Haerkens, F., Kirkels, L., van Amstel, M., Wouters, W., van Doornmalen, E., Hughes, S. A new use for old drugs: A Caenorhabditis elegans screening platform for anti-obesity properties of a chemical library. (manuscript in preparation)
  • van de Klashorst, D., van den Elzen, A., Weeteling, J., Roberts, M., Desai, T., Bottoms, L. and Hughes, S. (2020) Montmorency Tart Cherry (Prunus cerasus L.) acts as a calorie restriction mimetic that increases intestinal fat and lifespan in Caenorhabditis elegans. Journal of Functional Foods 68:103890
  • Hughes, S. and Celikel, T. (2019) Prominent inhibitory projections guide sensorimotor computation: An invertebrate perspective BioEssays 41(10):e1900088.
  • Heshof, R., Visscher, B., Prömel, S. and Hughes, S. (2019) Large-scale cultivation of Caenorhabditis elegans in a bioreactor using a labour-friendly fed-batch approach BioTechniques 67(1):33-39
  • Hughes, S., Vrinds, I., de Roo, J., Francke, C., Shimeld, S.M., Woollard, A. and Sato, S. (2019) DnaJ chaperones contribute to canalization. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology 331(3):201-212
  • van de Klashorst, D. and Hughes, S. (2018) Testing a sustainable source of taxol for the treatment of RUNX cancers using Caenorhabditis elegans. Student Research Conference E-journal 4
  • Mihaylova, Y., Abnave, P., Kao, D., Hughes, S., Lai, A., Jaber-hijazi, F., Kosaka, N. and Aboobaker, A.A. (2018) Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells. Nature Communications 9(1):3633
  • Dattani, A., Kao, D., Mihaylova, Y., Abnave, P., Hughes, S., Lai, A., Sahu, S. and Aboobaker, A. (2018) Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells. Genome Research 28(10):1543-1554
  • Hughes, S. and Woollard, A. (2017) “RUNX in invertebrates” Chapter 1 in RUNX proteins in Development and Cancer. Editors: Groner, Y., Liu, P., Neil, J.C., Speck, N.A., van Wijnen, A. Part of the Advances in Experimental Medicine and Biology Series published by Springer.
  • Sato, A., Kawashima, T., Fujie, M., Hughes, S., Satoh, N. and Shimeld, S.M. (2015) Molecular basis of canalization in an ascidian species complex adapted to different thermal conditions. Scientific Reports 5:16717
  • Hughes, S., Wilkinson, H., Gilbert, S.P.R., Kishida, M., Ding, S.S. and Woollard, A.C. (2014) The C. elegans TPR containing protein, TRD-1, regulates cell fate choice in the developing germline and epidermis. PLoS One 9(12):e114998.
  • LaBonty, M., Szmygiel, C., Byrnes, L.E., Hughes, S., Woollard, A. and Cram, E.J. (2014) CACN-1/Cactin plays a role in Wnt signalling in C. elegans. PLoS One 9(7):e101945
  • Hughes, S., Brabin, C., Appleford, P.J. and Woollard, A. (2013) CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells. Biology Open 2(7):718-27 Dr Samantha Hughes : Publication List 2
  • Prömel, S., Frickenhaus, M., Hughes, S., Mestek, L., Staunton, D., Woollard, A., Vakonakis, I., Schöneberg, T., Schnabel, R., Russ, A.P. and Langenhan, T. (2012) The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors. Cell Reports 2(2):321-31
  • Stürzenbaum, S.R., Zeitoun-Ghandour, S.M., Hodson, M., Charnock, J.M., Bundy, J.G., Want, E.J., Hughes, S. and Swain, S.C. (2009) Characterisation of Caenorhabditis elegans metallothioneins: Genomics, metabolomics and XFAS. Comparative Biochemistry and Physiology – Part A: Molecular & Integrative Physiology 154(1):S16
  • Jiang, G.C-T., Hughes, S., Stürzenbaum, S.R., Evje, L., Syversen, T. and Aschner, M. (2009) Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium. Toxicological Sciences 111(2):345-354
  • Hughes, S., Bundy, J., Want, E., Kille, P. and Stürzenbaum, S.R. (2009) The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins. Journal of Proteome Research 8(7):3512-3519
  • Calafato, S., Swain, S.C., Hughes, S., Kille, P. and Stürzenbaum, S.R. (2008) Knockdown of Caenorhabditis elegans cutc-1 exacerbates the sensitivity towards high levels of copper. Toxicological Sciences 106(2):384-391
  • Hughes, S. and Stürzenbaum, S.R. (2007) Single and double metallothionein knockout in the nematode C. elegans reveals cadmium dependent and independent toxic effects on life history traits. Environmental Pollution 145:395-400
  • Diaz, A., Hughes, S., Putman, R., Mogg, R. and Bond, J.M. (2006) A genetic study of sika (Cervus nippon) in the New Forest and in the Purbeck region, southern England: is there evidence of recent or past hybridization with red deer (Cervus elaphus)? Journal of Zoology 270:227-235
  • Bond, M., Porteous, R., Hughes, S., Mogg, R.M., Gardner, M.G and Reading, C.J. (2005) Polymorphic microsatellite markers, isolated using a simple enrichment procedure, in the threatened smooth snake (Coronella austriaca). Molecular Ecology Notes 5(1):42-44

COMPLETE LIST OF CONFERENCES

Platform presentations

  • COST Action Meeting Experimental models in aGPCR research. Online meeting, October 2020. Using C. elegans as a tool to explore aGPCR function. S. Hughes.
  • Dutch Zoological Society Annual Meeting in Groningen, November 2019: Learning and memory, an invertebrate perspective. S. Hughes.
  • Present Day Practical’s Symposium on Research Based Learning in Amsterdam, August 2019: A biochemical research major to prepare students for today’s challenges. J van Kilsdonk and S. Hughes
  • Nijmegen Health Symposia, February 2019: Caenorhabditis elegans: the model worm and its uses in exercise and human health research. S. Hughes.
  • High Content Screening Workshop in Porto, Portugal, February 2017: Development of a C. elegans based high-throughput screen to aid in the identification of compounds with an anti-obesity effect. S. Hughes
  • 19th International C. elegans Meeting in Los Angeles, USA, June 2013: CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells. S. Hughes, C. Brabin and A. Woollard. Dr Samantha Hughes : Publication List 3
  • The Society for Experimental Biology Symposium, The Hague, Holland, September 2007: The knockout of metallothionein and phytochelatin synthase in C. elegans: metal induced effects on life history and gene expression. S. Hughes, P. Kille and S.R. Stürzenbaum.

Poster presentations

  • European Worm Meeting, held virtually, June 2020: Tyrosine kinase inhibitors provide a significant health benefit, beyond that of cancer treatment. S. van Asten, N. Kolsters, D. van de Klashorst, L. Janssen, T. Schirris, S. Timmers and S. Hughes
  • 22nd International C. elegans Meeting in Los Angeles, USA, June 2019: Preparing the life science technicians of the future: An integrative approach to learning. J. van Kilsdonk, M. Timmermans and S. Hughes
  • Student Research Conference, Leiden, November 2018: Testing a sustainable source of taxol for the treatment of RUNX cancers using Caenorhabditis elegans. D. van de Klashorst and S. Hughes.
  • Protein Homeostatsis in Health and Disease, Cold Spring Harbour Laboratory, USA, April 2018: DnaJ chaperones are important in environmental and genetic canalisation. S. Hughes, I. Vrinds, G. M. Oba, J. De Roo, A. Woollard, S. Shimeld, A. Sato.
  • Figon DMD Congress on Innovation Drug Research in the Netherlands, October 2017: Using a high throughput screening system to identify novel anti-obesity compounds using the model organism Caenorhabditis elegans. S. Hughes, F. Haerkens, M. van Amstel, E. van Doornmalen, RAAK Elegant Consortium.
  • 21st International C. elegans Meeting in Los Angeles, USA, June-July 2017: Dissecting the molecular pathways underpinning the lifespan extension following exposure to Montmorency Tart Cherries. I. Vrinds, A. van den Elzen, T. Desai, M. Roberts, C. Lockman, L. Bottoms, S. Hughes
  • International Symposium of Flatworm Biology, Oxford, UK, August 2015: Investigating the molecular mechanisms governing neoblast sensitivity to radiation in the planarian Schmidtea mediterranea. N. Kosaka, P. Abnave, S. Hughes, J. Thompson, M. Hill and A. Aboobaker
  • European Worm Meeting, Berlin, May 2014: Identifying the direct targets of CEH-20/Pbx and UNC62/Meis during asymmetric divisions of the C. elegans stem-like seam cells. S. Hughes and A. Woollard
  • Oxford Cancer Research Centre Symposium, Oxford, UK, April 2012: The CEH-20/UNC-62 transcriptional partnership regulate stem-cell like seam cell proliferation in C. elegans by controlling division asymmetry. S. Hughes, C. Brabin and A. Woollard.
  • 18th International C. elegans Meeting in Los Angeles, USA, June-July 2011: The CEH-20/UNC-62 transcriptional partnership regulate seam cell proliferation by controlling division asymmetry. S. Hughes, C. Brabin and A. Woollard.
  • EMBO Conference Series C. elegans Development and Gene Expression in Heidelberg, Germany, June 2010: Identification of novel regulators of seam cell proliferation in a genome-wide screen. S. Hughes and A. Woollard.
  • 17th International C. elegans Meeting in Los Angeles, USA, June-July 2009: Novel regulators of RNT1/BRO-1 induced hyperplasia. S. Hughes, S. Maxwell and A. Woollard.
  • Runx transcription factors in Development and Disease at Oxford, UK, August 2009: Novel regulators of RNT-1/BRO-1 induced hyperplasia S. Hughes, S. Maxwell and A. Woollard. Dr Samantha Hughes : Publication List 4
  • 16th International C. elegans Meeting in Los Angeles, USA, June-July 2007: Life history and cadmium toxicosis in the global metallothionein knockout nematode C. elegans. S. Hughes, P. Kille and S.R. Stürzenbaum.

INVITED SEMINAR TALKS SINCE BEING AN INDEPENDENT RESEARCHER

  • 2019, seminar at the WUR: The worm in all of us; using Caenorhabditis elegans to investigate human health and disease.
  • 2019, seminar at Monash University, Melbourne: Development of a high throughput screen to aid in the identification of compounds with an effect on fat storage
  • 2019, seminar at the University of Queensland, Brisbane, Australia: Development of a high throughput screen to aid in the identification of compounds with an effect on fat storage.
  • 2017, seminar at Leeds University, UK: Using C. elegansin high throughput drug and chemical screens
  • 2017, seminar at Avans Hogeschool in Breda, The Netherlands: C. elegans: the model worm and its uses in cancer and disease research.
  • 2017, seminar at the Department of Pharmacology and Toxicology, Radboudumc: Using C. elegans in toxicology and disease research
  • 2017, Departmental seminar at the University of Leipzig, Germany: Development of a C. elegans based HTS to aid in the identification of compounds with an anti-obesity effect. Funded by the Genie Network of New C. elegans Investigators in Europe.